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China: The company recorded sales of US$ 13 mn in CY 2000 with breakeven at net level. The company expects revenue to grow at 15-20% p.a. in coming years. As competitive sourcing of bulk drugs in China is very easy, the company's operations in this country are already profitable. The company's four products including its top brand Cifran were registered in 2000. The company is targetting 8-10 product approvals every year in this market. Others: The Company's subsidiaries in the developing and lesser-developed countries such as Egypt, Malaysia, Nigeria, etc, are posting excellent growth, as there are very few companies, with similar skill sets as Ranbaxy in these countries.

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As amazing and gratifying as this case was, my most intense experience involved my own dog, just over a week ago. One very hot day in late July, my goddaughter Sophie took our 14-year-old lab mix dog for a stroll where we live in upcountry Maui. Half an hour later, I received a frantic phone call: "Ackee's not doing so well. He can't breathe". My husband jumped in the car and brought girl and dog back home. I took one look at our best friend and thought, "oh no". The dog was moribund, lying on his side in severe respiratory distress, suffering from heat exhaustion. A little medicine circle had sprung up around him: Sophie was beside herself, her brother Hugo cradled Ackee's head and tried to calm him down and encourage him to breathe, another friend hosed and iced him down, Reggie the cat and me. Meanwhile Ackee's gums and tongue had become increasingly cyanotic and were now blue. Since I started doing strictly TCVM house calls, I have no western biomedical emergency drugs on hand, so I grabbed the only resource I have: acupuncture needles and the electroacupuncture unit. I started putting needles wherever they seemed needed: BL10, 12, 13, 14, Ding Chuan, LU1, 5, 7; LI4, 10, 11; PC8; SI 8; BL21, 22, 23, 24, Shen Shu, Bai Hui, KI 1, 3: GV1, GV20, ST36, 44; Er Jian, Wei Jian and some other points that I probably just made up. As all these needles were flying in, it did cross my mind that I might be overdoing it, and sending conflicting messages, confusing the Qi. I fired up the electric unit starting at 20 Hz, all the while watching Ackee.

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You can find these teas at most health food stores and now many grocery stores, for instance, . WASHINGTON -- LNS ; -- American food and drug ad ministration advisors hav e recommended a drug company b e allowed to conduct tests on wome n with a drug 'which causes cancer i n laboratory animals . The drug, tinidazole i s manufactured by Ortho Pharmaceutical, a division of Johnson & Johnson . It is intended as a rival to flagyl, or metronidazole, for the treatment of trichomona s vaginitis, a common vaginal infection. The FDA Advisory committee o n obstetrics and gynecology has als o recommended flafyl be allowed to , remain on the market . Flagyl, which has had a profitable monopoly on the marke t since 1963, has been shown to caus e cancer in laboratory animals . Tinidozole is chemically related to falgyl which is commonl y prescribed by Canadian doctors . In a letter to FDA commissione r Alexander Schmidt, urging the FDA to not allow human testing o f Tinidazole, the health research group cited studies completed i n 1973 from which the FDA concluded that tinidazole i s "associated with a statistically significant increase in the incidence of malignant mammar y gland breast ; tumors in femal e mice . "In comparison to metronidazole flagtl ; , about the only clear-cut statement which can be made here is that both of these agents are highly significant carcinogens . " When in 1972 doctors discovere d flagyl is carcinogenic Ortho halted its investigation of Tinidazole until studies could determine whether it too is cancer-producing . But despite the studies' finding , Ortho still asked to do huma n testing . "FDA's failure to regulat e against flagyl -- a drug now show n to be cancer causing in six different studies -- seems to hav e been taken as a challenge to Ortho to see if they too can push the FD A to allow marketing a carcinogenic drug for a relatively non-serious condition, " writes HRG, a Washington-based public interes t group . HRG goes on to say tha t authorizing tests on wome n represents a "giant retreat from previous FDA policy . " A spokeswoman for the grou p calls it "a whole new precedent fo r human drugs . Up till now, if the FDA knew something cause d cancer in animals, it wouldn' t allow human testing . "Tinidazole is a big step back ward for all of our health . " Richard Crout, director of the FDA's bureau of drugs, denied an y "retreat", saying that FDA polic y has been to balance risks agains t benefits even when carcinogen s are involved . And, as Dr . Crout was quoted a s saying in Medical World News, o f June 7, "I don't believe our society has made the judgment tha t cancer is an over-riding concern . I'll tell you why . It hasn't banned cigarettes ." ; Crout also claimed flagyl and tinidazole are intended for short term use, and in low dosages . This indicates a "vanishing possibilit y of producing cancer, " he said . However, according to Dr . Jane Hodgeson, a specialist i n trichomonas vaginitis who spoke to the advisory committee, at least 3 0 percent of flagyl users suffer a recurrence of the infection within a few months, which usually leads t o another round of treatment with the drug . One study by HRG found on e course of treatment of flagyl onl y 60 per cent effective and anothe r found it only 24 per cent effective . Hodgeson said America n medical literature contains no mention of flagyl's carcinogenicity, except for a 197 2 paper in the Journal of the National Cancer Institute, "which is not widely read by clinicians . " Hodgeson also told the advisor y committee that flagyl in its ora l form is prescribed "far to o casually and freely . largely because of insufficient warning . " Doctors write an estimated 2 . 2 million in the U .S . alone perscriptions a year for flagyl makin g it one of the most commonl y prescribed drugs . And bout one-third of th e 2, 260, 000 prescriptions for flagyl i n 1972 were for ailments vulvitis , non-specific vaginitis, and fungu s infections and kamagra.

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Nicotinic Acid. Niacin - CD for all aviation personnel as a supplement over 20 mg day. c. Antimicrobials, Antifungals, and Antivirals. 1 ; Augmentin Amoxicillin ; , Sulfonamides Bactrim Septra DS ; , Cephalosporins, Clindamycin remember Pseudomembranous colitis ; , Metronidazole Flaggyl ; , Macrolides, Nitrofurantoin Macrodantin ; watch for pneumonitis or peripheral neuropathy ; , Penicillins, Quinolones, Tetracyclines Doxycycline Vibramycin ; For Prophylaxis - Includes Malaria Or Leptospirosis ; , Ethambutol Hydrochloride Myambutol ; monitor serum uric acid during treatment ; , Rifampin Rifadin ; 2 ; Chloroquine Aralen ; or Chloroquine Primiquine. See Malarial prophylaxis paragraph of this section for more information on antimalarials. 3 ; Fluconazole Diflucan ; , Griseofulvin Gris-peg, Fulvicin ; if under close observation by local flight surgeon. Watch for bone marrow suppression. Grounded for first 4 weeks of use. Itraconazole Sporanox ; has a safer profile than ketaconazole, and need not be used on a chronic basis to be effective. Recommended use in aviation personnel is to administer in weeklong pulses each month for four to six cycles. Member should be grounded for the first 48 hours of each cycle. 4 ; Acyclovir Zovirax ; [ Valcyclovir Valtrex ; , and Famcyclovir Famvir ; are acceptable alternatives ; ]. Oral or topical administration. a ; Short-term use 1 week or less ; does not require a waiver. A minimum of 24 hours of observation to insure the lack of side effects and the overall general health of the member should be considered prior to return to flight status.

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Drug Doses - Hospital Weight kg ; : IMFERON - see IRON IPECACUANA SYRUP, give once, oral ml IRON Amp 2 ml or Imferon ; . Do not give more than 5 ml IM per day. Total dose, IM . ml Tab Ferrous sulphate or Fefol ; 200 mg oral . tab If iron suspension - Sulphate Fumarate or Gluconate - is available, the dose is based on 6 mg kg of elemental iron. ; . ISONIAZID INAH ; Tab 100 mg, 10-20 mg kg daily for 2 months . tab THEN 15-20 mg kg twice a week, oral . tab ISOPRENALINE KETAMINE KETALAR ; 500 mg 10 ml IV 2 mg kg 0.04 ml kg ; SLOWLY . ml IM: first dose 10 mg kg 0.2 ml kg ; . further doses 5 mg kg 0.1 ml kg ; . LAMPRENE - see CLOFAZIMINE LANOXIN - see DIGOXIN LARGACTIL - see CHLORPROMAZINE LASIX - see FRUSEMIDE LYTIC COCKTAIL. Pethidine 50 mg 1 ml ; + promethazine 25 mg 1 ml ; + sterile water 8 ml. MAXIMUM dose 0.3 ml kg IV MAGNESIUM HYDROXIDE MIXTURE MILK OF MAGNESIA ; , ml daily MALOPRIM pyrimethamine 12.5 mg + dapsone 100 mg ; . Tab, weekly oral tab MANNITOL 20%. 1.25-2.5 ml kg 0.25-0.5 g kg ; IV over 30 minutes. May be repeated every 6 hours ml MEBENDAZOLE. Tab 100 mg BD for 3 days tab METHYLDOPA ALDOMET ; . Tab 250 mg, 5-10 mg kg tab METRONIDAZOLE FLAGYL ; Tab 200 mg or 250 mg, 15-20 mg kg TID for 5 days, oral tab Suppos 500 mg for half dose, split lengthways ; , TID into rectum suppos MOGADON - see NITRAZEPAM and lansoprazole.

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Under article 161 of the German Stock Corporation Act, the Board of Management and the Supervisory Board of Bayer AG are required to issue an annual declaration that the company has been, and is, in compliance with the recommendations of the "Government Commission on the German Corporate Governance Code" as published by the Federal Ministry of Justice in the official section of the electronic Federal Gazette Bundesanzeiger ; , or to advise of any recommendations that have not been, or are not being, applied.The declaration pursuant to article 161 of the Stock Corporation Act shall be available to shareholders at all times. For the past, the following declaration refers to the November 7, 2002 version of the Code. For the current and future corporate governance practice of Bayer AG, the following declaration refers to the recommendations in the May 21, 2003 version of the Code. The Board of Management and the Supervisory Board of Bayer AG hereby declare that the company is in compliance with the recommendations of the "Government Commission on the German Corporate Governance Code" as published by the Federal Ministry of Justice in the official section of the electronic Federal Gazette and has been in compliance since issuance of the last declaration of conformity in December 2002. Only the following recommendations were not, or are not being, applied or were, or are being, applied in a modified form: 1. Section 2.3.3: The company shall facilitate the personal exercising of shareholders' rights. The company shall also assist the shareholders in the use of proxies. The Board of Management shall arrange for the appointment of a representative to exercise shareholders' voting rights in accordance with instructions. As in the past, stockholders attending the Annual Stockholders' Meeting can exercise proxy voting rights and issue instructions via proxy voting cards.There are plans to facilitate the exercising of voting rights through the appointment of a representative beginning in 2004. 2. Section 3.8, Paragraph 2: If the company obtains D&O [Directors' and Officers' Liability] insurance for the Board of Management and the Supervisory Board, a suitable deductible should be agreed. The present D&O insurance for Bayer AG does not cover an intentional breach of duty.To the extent insurance coverage is provided, there is no deductible for members of the Board of Management or the Supervisory Board. Bayer AG has obtained personal declarations of obligation from the members of its Board of Management and Supervisory Board concerning the payment of a deductible, even if insurance coverage otherwise exists under D&O insurance obtained by the company. Pursuant to these declarations, members of the Board of Management who cause damage to the company or third parties through gross negligence under German standards in their Board of Management activity are to pay for such damage up to an amount equivalent to half of their annual income in the year in which the damage occurs. Members of the Supervisory Board who cause damage to the company or third parties through gross negligence under German standards in their Supervisory Board activity are to pay for such damage up to an amount equivalent to the variable portion of their respective annual compensation as members of the Supervisory Board for the year in which the damage occurs.This does not limit their liability toward the company or third parties. 3. Section 4.2.3, Paragraph 2, Sentence 4: For exceptional, unforeseen developments, the Supervisory Board in connection with stock option programs or similar arrangements for boards of management ; should agree on an possible limit cap ; . In connection with future stock option programs or similar arrangements, the Supervisory Board intends to reach corresponding agreements with the members of the Board of Management. 4. Section 5.4.5: The compensation of the Supervisory Board shall also take into account serving as the Chair and membership in committees. This was not yet the case until the corresponding amendment of the Articles of Incorporation at the Annual Shareholders' Meeting on April 25, 2003. 5. Section 7.1.4: Under this recommendation, the company should publish a list of certain other legal entities stating, among other things, their operating results for the last fiscal year. The operating results of other legal entities are published only to the extent they are available when Bayer's financial statements are prepared. Leverkusen, December 2003 Amendment to the declaration of December 2003.The following recommendation is being applied in a modified form in 2004: Section 7.1.2, sentence 2: The Consolidated Financial Statements shall be publicly accessible within 90 days of the end of the fiscal year; interim reports shall be publicly accessible within 45 days of the end of the reporting period. The interim reports for the first half and third quarter of 2004 will not be published within 45 days of the respective closing dates because numerous sets of financial statements, including consolidated Group statements, will have to be prepared at that time in connection with the carve-out of certain chemicals and polymers activities. Leverkusen, January 2004 For the Board of Management For the Supervisory Board. PRICE, Gerald B UNDERDOWN, Brian J AW, E. Jom BRASH, John L BRIDGER, William A BRUCE, Caroline CHAYE, Helena H CHELIAK, William DORE, Sylvie DOUVILLE, Philippe EARLE, Mary L FILION, Mario GRIFFITH, Irwin HOBMAN, Marita McGill University McMaster University University of Ottawa McMaster University University of Western Ontario University of British Columbia MediGene Inc. San Diego, California ; Galileo Genomics cole de technologie suprieure Polaris Biosciences Earle & Associates Inc. Universit de Montral ViRexx Medical Corporation Biomira Inc. HOWARD-TRIPP, James KARLIK, Stephen J KLEIN, Steven J LAPORTE, Audrey MARSMAN, Kathleen MATHESON, Ronald C MIERNICKI STEEG, Carol RADZIUK, Jerry M RUEDY, John SECHLEY, Konrad A SHINDLER, David WALLENBURG, John C ZAKY, Safwat G Labopharm Inc. University of Western Ontario CANVAC University of Toronto Borden Ladner Gervais LLP University Technologies International Inc. Queen's University Ottawa Hospital-Civic Site Dalhousie University Gowling Lafleur Henderson LLP Milestone Medica McGill University University of Toronto.

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