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References 1 Quan SF, Carmona RH. Frontiers of knowledge in sleep and sleep disorders: opportunities for improving health and quality of life. J Clin Sleep Med. 2005; 1: 83-89.
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Rhonda Rubin, Sharon Silbiger, Leonarda Sablay, Joel Neugarten Abstract We examined the interrelation between systemic hypertension, hyperlipidemia, and progressive renal injury in experimental glomerulonephritis. Induction of nephrotoxic serum nephritis in Sprague-Dawley rats led to systemic hypertension and hyperlipidemia. Four groups of rats were studied over a 16-week period: 1 ; untreated nephritic rats; 2 ; nephritic rats treated with hydralazine, reserpine, and ladix AH 3 ; nephritic rats treated with lovastatin 4 mg kg ; Lova and 4 ; nephritic rats treated with combined antihypertensive lipidlowering therapy AH Lova ; . Systolic blood pressure rose progressively in untreated rats 1524 mm Hg at weeks ; . Blood pressure was reduced by antihypertensive therapy P .001 ; 1082 mmHg in the AH group and 1113 mm Hg in the AH Lova group ; but remained elevated in animals treated with lovastatin alone P .05 ; 1563 mmHg in the Lova group ; . Serum cholesterol rose progressively in untreated rats 3.700.85 mmol L [14333 mg dL] at 16 weeks ; . The rise in serum cholesterol was prevented by lovastatin therapy .001 ; 2.220.41 mmol L [8616 mg dL] in the Lova group and 2.090.52 mmol L [81 2 mg dL] in the AH Lova group ; but not antihypertensive therapy F .05 ; 2.920.65 mmol L [11325 mg dL] in the AH group ; . Proteinuria was reduced by antihypertensive therapy P .001 ; and lipid-lowering therapy P .05 ; 16-week values: 1.0690.167 g d in untreated rats, 0.6630.164 g d in the Lova group, 0.3920.051 g d in the AH group, and 0.1760.035 g d in the AH Lova group ; . Glomerular injury score was significantly reduced by antihypertensive therapy P .01 ; and lipid-lowering therapy f .05 ; . Glomerular injury score was lowest in animals receiving combined therapy, reflecting an interaction between these therapies P .01 ; untreated, 17329; Lova, 12824; AH, 11122; AH Lova, 4811 ; . Our results suggest that both hypertension and hyperlipidemia accelerate glomerular sclerosis in experimental glomerulonephritis and that combined therapy of these disorders may best limit progressive renal injury. Hypertension. 1994 3: 92-95. ; Key Words hyperlipidemia glomerulonephritis hypertension and nexium.
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